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Additional Regenerative Traits of Adult Stem Cells Adult stem cells have also been shown to communicate with the nucleus pulpusus (NP) cells in a bidirectional manner. The outcomes of this trial will be based on assessment of primary and secondary endpoints at 6 and 12 months after treatment of supplementary allograft compared to conservative care in subjects who have pain attributable to disc degeneration as judged by MRI scoring (Pfirrmann), physical examination, and patient reported pain. 2015 May;39(5):927-34. doi: 10.1007/s00264-014-2664-8. Right now, the standard treatment involves medication, physical therapy, and changes in diet and exercise habits. Intervertebral disc (IVD) has the role of shock absorber of the spine and amortise compressive loading forces [ 2 ]. 2016 Oct-Dec;30(4 Suppl 1):173-179. Degenerative Disc Disease: A Review of Clinical Trials and Future Directions Brenton Pennicooke , Yu Moriguchi , Ibrahim Hussain , Lawrence Bonssar , Roger Härtl 1. Identification of the novel biologics to arrest IDD phenotype may potentiate disc repair in future. Browse Clinical Trials. Intervertebral disc regeneration: From cell therapy to the development of novel bioinspired endogenous repair strategies. Intervertebral disc degeneration (IDD) is considered one of the most important causes of low back pain [ 1 ]. Share this article. Cell Physiol Biochem. Clinical Trials and You—NIH has this resource if you are interested in finding a clinical trial for your medical condition. Disc cells — A third company — DiscGenics — is looking to begin a Phase 1 trial this year with actual disc cells. Cell and Gene Therapy for Spine Regeneration: Mammalian Protein Production Platforms for Overproduction of Therapeutic Proteins and Growth Factors. • Disc repair is both a minimally invasive as well as motion preserving technique to treat symptomatic degenerative disc disease earlier and less invasively.  |  Biological interventions have been investigated with an attempt to regenerate the IVD by restoring its matrices and cell activities. Finally, we present an overview of an investigational cell therapy called IDCT (Injectable Discogenic Cell Therapy), which is currently under evaluation in multiple double-blind clinical trials overseen by major regulatory agencies. There is an indeterminate overlap of up to 14 days between the end of the Screening Phase and the start of the Active Phase for individual subjects in order to evaluate the protocol, and consent to their participation. Get the latest research information from NIH: You have reached the maximum number of saved studies (100). Intervertebral disc (IVD) degeneration (IDD) is considered as one of the major causes for low back pain (LBP). Injectable formulation of juvenile chondrocytes, designed to regenerate cartilage and restore disc function given the green signal. 2019 Apr;43(4):755-760. doi: 10.1007/s00264-019-04324-y. • Safe: Yes • Efficacious: ? Surgical Waste Intervertebral Disc Tissue Analysis Rochester, MN The overall aim of this project is to study the interaction between white blood cells (inflammation) and disc degeneration. Multiple pre-clinical animal trials have been conducted, but with conflicting outcomes. Twenty million hUCMSCs will be injected into the lumbar disc of the enrolled patients in this non-random, self-controlled and single-dose open study design. Viable Allograft Supplemented Disc Regeneration in the Treatment of Patients With Low Back Pain With or Without Intervertebral Disc Herniation - VAST Trial, Santa Monica, California, United States, 90404, Walnut Creek, California, United States, 94598, Indianapolis, Indiana, United States, 46278, Brownstown, Michigan, United States, 48183, Virginia Beach, Virginia, United States, 23454. Epub 2015 Feb 5. -, J Bone Joint Surg Am. Med Hypotheses. This review summarizes the current clinical trials that explore the efficacy of covering cell-, growth factor-, and small molecule-based approaches. HIV, Hepatitis), Agree to use appropriate contraception; not planning on becoming pregnant for 24 months after treatment. He is currently leading multiple clinical trials evaluating the safety and efficacy of mesenchymal stem cells (MSCs) in the treatment of low back pain, including a phase III trial of intradiscal allogeneic bone marrow-derived MSC transplantation and a phase I trial of autologous adipose-derived MSC transplantation in degenerative disk disease (DDD). Intervertebral disc (IVD) degeneration (IDD) is considered as one of the major causes for low back pain (LBP). The impact and distinction of 'lipid healthy but obese' and 'lipid abnormal but not obese' phenotypes on lumbar disc degeneration in Chinese. All subjects randomized to Placebo will undergo injection with saline into the nucleus pulposus of the degenerated disc. 2019 Jun;146:306-324. doi: 10.1016/j.addr.2018.04.017. 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